Lyme disease


Lyme disease is an illness caused by borrelia bacteria. Humans usually get Lyme disease from the bite of a tick carrying the bacteria.

Ticks that can carry borrelia bacteria live throughout most of the United States. But Lyme disease is most common in the upper Midwest and the northeastern and mid-Atlantic states. It's also common in Europe and in south central and southeastern Canada.

You're at risk of Lyme disease if you spend time where the ticks live, such as grassy, brushy or wooded areas. Taking safety measures in these areas can lower the risk of Lyme disease.


A tick bite may look like as a tiny, itchy bump on your skin, much like a mosquito bite. This doesn't mean you have a tick-borne disease. Many people will not notice they've had a tick bite.

The symptoms of Lyme disease vary. They usually show up in stages. But the stages can overlap. And some people don't have symptoms of the typical early stage.

Stage 1

Early symptoms of Lyme disease usually happen within 3 to 30 days after a tick bite. This stage of disease has a limited set of symptoms. This is called early localized disease.

A rash is a common sign of Lyme disease. But it doesn't always happen. The rash is usually a single circle that slowly spreads from the site of the tick bite. It may become clear in the center and look like a target or bull's-eye. The rash often feels warm to the touch, But it's usually not painful or itchy.

Other stage 1 symptoms include:

  • Fever.
  • Headache.
  • Extreme tiredness.
  • Joint stiffness.
  • Muscle aches and pains.
  • Swollen lymph nodes.

Stage 2

Without treatment, Lyme disease can get worse.  The symptoms often show up within 3 to 10 weeks after a tick bite. Stage 2 is often more serious and widespread. It is called early disseminated disease.

Stage 2 may include the stage 1 symptoms and the following:

  • Many rashes on other parts of the body.
  • Neck pain or stiffness.
  • Muscle weakness on one or both sides of the face.
  • Immune-system activity in heart tissue that causes irregular heartbeats.
  • Pain that starts from the back and hips and spreads to the legs.
  • Pain, numbness or weakness in the hands or feet.
  • Painful swelling in tissues of the eye or eyelid.
  • Immune-system activity in eye nerves that causes pain or vision loss.

Stage 3

In the third stage, you may have symptoms from the earlier stages and other symptoms. This stage is called late disseminated disease.

In the United States, the most common condition of this stage is arthritis in large joints, particularly the knees. Pain, swelling or stiffness may last for a long time. Or the symptoms may come and go. Stage 3 symptoms usually begin 2 to 12 months after a tick bite.

The type of Lyme disease common in Europe can cause a skin condition called acrodermatitis chronic atrophicans. The skin on the backs of the hands and tops of the feet get discolored and swell. It also may show up over the elbows and knees. More-serious cases may cause damage to tissues or joints.

This skin condition may show up many months to many years after a tick bite.

When to see a doctor

Most people who get Lyme disease don't remember having a tick bite. And many symptoms of Lyme disease relate to other conditions. See your health care provider if you have Lyme disease symptoms. An early diagnosis and proper treatment can improve outcomes.

If you know you had a tick bite or might have been around ticks, watch for symptoms. If they show up, see your care provider as soon as possible.

Lyme disease rash on different skin colors.


Lyme disease is caused by borrelia bacteria. In North America, the black-legged tick, also called the deer tick, mainly carry the bacteria.

In Europe, a different species of borrelia causes Lyme disease. Ticks carry the bacteria. These ticks are known by a few names, including castor bean tick, sheep tick or deer tick.

Tick bites

Ticks feed on blood by attaching to a host's skin. The tick feeds until it's swollen to many times its typical size. Deer ticks can feed on a host's blood for several days.

Ticks pick up bacteria from a host, such as a deer or rodent. They don't get sick. But they can pass the bacteria to another host. When an infected tick feeds on a person, the bacteria can move to the person's bloodstream. The bacteria are less likely to spread Lyme disease if you remove the tick within 24 hours.

Both young and adult ticks can carry the disease. Young ticks are tiny and hard to spot. You may not notice if a young tick bites you.

Deer tick

Risk factors

Your risk for getting Lyme disease depends on if you spend time where they are likely to live. This includes the:

  • Region. Deer ticks that carry Lyme disease are widespread. They are mostly found in the upper Midwest, the northeastern and mid-Atlantic states, and in south central and southeastern Canada. The castor bean tick is found throughout Europe.
  • Habitat. Ticks live in wooded, shrubby or grassy areas.
  • Time of year. The risk of infection is greater in the spring, summer and fall. But ticks can be active any time the temperature is above freezing.


Some people with Lyme disease report symptoms that continue after treatment. These longer-lasting symptoms may include:

  • Arthritis that begins with Lyme disease and doesn't improve.
  • Body aches and pains.
  • Constant or frequent tiredness.
  • Memory complaints.

These conditions are not clearly understood. Some people with these symptoms may be diagnosed with post-treatment Lyme disease syndrome, or PTLDS. These long-lasting problems may be caused by:

  • Incomplete treatment.
  • Reinfection with Lyme disease.
  • Immune system response to fragments of killed bacteria.
  • Immune system activity that harms healthy tissues, also called autoimmunity.
  • Conditions other than Lyme disease that have not been diagnosed.


The best way to prevent Lyme disease is to avoid tick bites when you are outdoors. Most ticks attach themselves to your lower legs and feet as you walk or work in grassy, wooded areas or overgrown fields. After a tick attaches to your body, it often crawls upward to find a spot to burrow into your skin.

If you're in or plan to be in an area where ticks are likely to live, follow these tips to protect yourself.

Use tick repellents

  • Spray your outdoor clothing, shoes, tent and other camping gear with a repellent that has 0.5% permethrin. Some gear and clothing may be pre-treated with permethrin.
  • Use an insect repellent registered with the Environmental Protection Agency on any exposed skin, except your face. These include repellents that contain DEET, picaridin, IR3535, oil of lemon eucalyptus (OLE), para-menthane-diol (PMD) or 2-undecanone.
  • Do not use products with OLE or PMD on children under age 3.

Dress for protection

  • Wear light-colored clothing that makes it easier for you or others to see ticks on your clothing.
  • Avoid open-toed shoes or sandals.
  • Wear long-sleeved shirts tucked into your pants.
  • Wear long pants tucked into your socks.

Check for ticks

  • Shower as soon as possible to wash off any loose ticks. Check for ticks that may have burrowed.
  • Use a mirror to check your body well. Pay attention to your underarms, hair and hairline. Also check your ears, waist, and the area between your legs, behind your knees, and inside your bellybutton.
  • Check your gear. Before you wash your outdoor clothes, put them in the dryer on hot for at least 10 minutes to kill ticks.

Other tips

  • Do a daily inspection for ticks on any pet that spends time outdoors.
  • Stay on clear paths as much as possible in wooded and grassy areas.


If you live where Lyme disease is common, the rash might be enough for a diagnosis.

A diagnosis usually depends on the following:

  • A review of all signs and symptoms.
  • A history of known or possible exposure to ticks.
  • Blood tests to find disease-fighting antibodies to the bacteria.


Antibiotics are used to treat Lyme disease. In most cases, recovery will be quicker and more complete the sooner treatment begins.

Antibiotic pills

The standard treatment for Lyme disease is an antibiotic taken as a pill. The treatment usually lasts 10 to 14 days. Treatment may be longer depending on your symptoms. It's important to take all pills as directed even if you're feeling better.

IV antibiotic

Your care provider may prescribe an antibiotic given directly into a vein, also called an intravenous (IV) antibiotic. An IV antibiotic may be used for more-serious disease, especially if you have symptoms of:

  • Long-lasting arthritis.
  • Disease affecting the nervous system.
  • Disease affecting the heart.

Preventive use of antibiotics

Your provider may prescribe an antibiotic as a preventive measure, also called prophylaxis, only if all three of these conditions happen:

  • The biting tick is known to be a deer tick.
  • You live in or recently visited an area where Lyme disease is common.
  • The tick was attached to the skin for 36 hours or more.

Antibiotics are the only proven treatment for Lyme disease. Other treatments have not been shown to work or haven't been tested.

Illness after Lyme disease

You may have heard the term "chronic Lyme disease." Some people use the term to refer to long-term symptoms they think may be linked to an earlier case of Lyme disease. But that term isn't well-defined. Research has found that these symptoms aren't related to ongoing illness caused by borrelia bacteria. Research also shows that continued use of antibiotics doesn't improve these symptoms.

If you have new health concerns or continuing health problems after Lyme disease, talk to your provider. Symptoms may be due to many potential causes. Your provider can help you figure out the cause of your symptoms and find the right treatment for you.

Lifestyle and home remedies

If you find a tick on your body, follow these steps to remove it:

  • Gloves. If you have them, wear medical gloves or similar gloves to protect your hands.
  • Tweezers. Use fine-tipped tweezers to grab the tick firmly near its mouth and as close to your skin as possible.
  • Removal. Steadily and slowly pull the tick's body away from your skin without jerking or twisting it. If parts of the mouth remain, remove them with clean tweezers.
  • Disposal. Kill the tick by putting it in alcohol. To avoid exposure to possible bacteria, don't crush the tick. The dead tick can be flushed down a drain or toilet. Or it can be lightly wrapped in tape and thrown in the trash, or placed in a sealed bag and stored in a freezer.
  • Storage. A tick can be evaluated later if you think you have a tick-borne disease. Put the tick in a container, label it with the date and place it in the freezer.
  • Cleanup. After removing the tick, first use soap and water to wash your hands and the site of the tick bite. Then clean the site and your hands with rubbing alcohol.

Don't put petroleum jelly, fingernail polish, rubbing alcohol or a hot match on to the tick.

Preparing for an appointment

You're likely to see your primary care provider or an emergency room doctor, depending your symptoms. You may also see a doctor trained in infectious diseases.

If you kept a removed tick, bring it to the appointment. If you've done recent outdoor activities and may have had a tick bite or may have a tick-borne illness, be ready to answer these questions:

  • If a tick bit you, when did it happen?
  • When do you think you were exposed to ticks?
  • Where have you been while doing outdoor activities?

What to expect from your doctor

Be prepared to answer these additional questions and write down the answers before your appointment.

  • What symptoms have you experienced?
  • When did they begin?
  • Has anything improved the symptoms or worsened them?
  • What medicines, dietary supplements, herbal remedies and vitamins do you take regularly?
  • Have you made any recent changes to medications?
  • Are you allergic to any medications, or do you have any other allergies?

Content From Mayo Clinic Updated: 02/09/2023
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