Long QT syndrome


Long QT syndrome (LQTS) is a heart rhythm disorder that causes fast, chaotic heartbeats. The irregular heartbeats can be life-threatening. LQTS affects the electrical signals that travel through the heart and cause it to beat.

Some people are born with changes in DNA that cause long QT syndrome. This is known as congenital long QT syndrome. LQTS also can happen later in life due to some health conditions, certain medicines or changes in the levels of body minerals. This is called acquired long QT syndrome.

Long QT syndrome can cause sudden fainting and seizures. Young people with LQTS syndrome have a higher risk of sudden cardiac death.

Treatment for long QT syndrome includes lifestyle changes and medicines to prevent dangerous heartbeats. Sometimes a medical device or surgery is needed.


The most common symptom of long QT syndrome is fainting, also called syncope. A fainting spell from LQTS can happen with little to no warning.

Fainting happens when the heart beats in an irregular way for a short time. You might faint when you're excited, angry or scared, or during exercise. If you have LQTS, things that startle you can cause you to pass out, such as a loud ringtone or an alarm clock.

Before fainting happens, some people with long QT syndrome might have symptoms such as:

  • Blurred vision.
  • Lightheadedness.
  • Pounding heartbeats called palpitations.
  • Weakness.

Long QT syndrome also can cause seizures in some people.

Babies born with LQTS may have symptoms during the first weeks to months of life. Sometimes the symptoms start later in childhood. Most people born with LQTS have symptoms by age 40. Symptoms of long QT syndrome sometimes happen during sleep.

Some people with long QT syndrome (LQTS) do not notice any symptoms. The disorder may be found during a heart test called an electrocardiogram. Or it may be discovered when genetic tests are done for other reasons.

When to see a doctor

Make an appointment for a health checkup if you faint or if you feel like you have a pounding or fast heartbeat.

Tell your healthcare team if you have a parent, brother, sister or child with long QT syndrome. Long QT syndrome can run in families, which means it can be inherited.


Long QT syndrome (LQTS) is caused by changes in the heart's electrical signaling system. It doesn't affect the shape or form of the heart.

To understand the causes of LQTS, it may help to know how the heart usually beats.

In a typical heart, the heart sends blood out to the body during each heartbeat. The heart's chambers squeeze and relax to pump the blood. The heart's electrical system controls this coordinated action. Electrical signals called impulses move from the top to the bottom of the heart. They tell the heart when to squeeze and beat. After each heartbeat, the system recharges to prepare for the next heartbeat.

But in long QT syndrome, the heart's electrical system takes longer than usual to recover between beats. This delay is called a prolonged QT interval.

Long QT syndrome usually falls into two groups.

  • Congenital long QT syndrome. You're born with this type of LQTS. It's caused by changes in DNA that are passed down through families. That means it is inherited.
  • Acquired long QT syndrome. This type of LQTS is caused by another health condition or medicine. It usually can be reversed when the specific cause is found and treated.

Causes of congenital long QT syndrome

Many genes and gene changes have been linked to long QT syndrome (LQTS).

There are two types of congenital long QT syndrome:

  • Romano-Ward syndrome. This more common type happens in people who get only a single gene change from one parent. Receiving a changed gene from one parent is known as an autosomal dominant inheritance pattern.
  • Jervell and Lange-Nielsen syndrome. This rare form of LQTS usually happens very early in life and is severe. Children with this type of LQTS also are deaf. In this syndrome, children get the gene change from both parents. This is called an autosomal recessive inheritance pattern.

Causes of acquired long QT syndrome

A medicine or other health condition can cause acquired long QT syndrome.

If a medicine causes acquired long QT syndrome, the disorder may be called drug-induced long QT syndrome. More than 100 medicines can cause prolonged QT intervals in otherwise healthy people. Medicines that can cause LQTS include:

  • Some antibiotics, such as erythromycin (Eryc, Erythrocin, others), azithromycin (Zithromax) and others.
  • Some antifungal medicines used to treat yeast infections.
  • Water pills, also called diuretics, that cause the body to remove too much potassium or other minerals.
  • Heart rhythm medicines called anti-arrhythmics, which can make the QT interval longer.
  • Some medicines used to treat mental health conditions such as anxiety and depression.
  • Some medicines used to treat upset stomach.

Always tell your healthcare professional about all the medicines you take, including those you buy without a prescription.

Health conditions that can cause acquired long QT syndrome include:

  • Body temperature below 95 degrees Fahrenheit (35 degrees Celsius), a condition called hypothermia.
  • Low calcium, also called hypocalcemia.
  • Low magnesium, also called hypomagnesemia.
  • Low potassium, also called hypokalemia.
  • A tumor of the adrenal gland that usually is not cancer, called pheochromocytoma.
  • Stroke or brain bleed.
  • Underactive thyroid, also called hypothyroidism.
Chambers and valves of the heart

Risk factors

Things that may raise the risk of long QT syndrome (LQTS) include:

  • A history of cardiac arrest.
  • Having a parent, brother, sister or child with long QT syndrome.
  • Using medicines known to cause prolonged QT intervals.
  • People who are assigned female at birth who take certain heart medicines.
  • A lot of vomiting or diarrhea, which can cause changes in body minerals such as potassium.
  • Eating disorders such as anorexia nervosa, which also cause changes in the levels of body minerals.

If you have long QT syndrome and want to become pregnant, tell your healthcare professional. Your care team carefully checks you during pregnancy to help prevent things that can trigger LQTS symptoms.


Usually after an episode of long QT syndrome (LQTS), the heart goes back to a regular rhythm. But sudden cardiac death can happen if the heart rhythm isn't quickly corrected. The heart rhythm may reset on its own. Sometimes, treatment is needed to reset the heart rhythm.

Complications of long QT syndrome may include:

  • Torsades de pointes ("twisting of the points"). This is a life-threatening fast heartbeat. The heart's two lower chambers beat fast and out of rhythm. The heart pumps out less blood. The lack of blood to the brain causes sudden fainting, often without warning.

    If a long QT interval lasts for a long time, fainting can be followed by a full-body seizure. If the dangerous rhythm does not correct itself, then a life-threatening arrhythmia called ventricular fibrillation follows.

  • Ventricular fibrillation. This type of irregular heartbeat causes the lower heart chambers to beat so fast that the heart trembles and stops pumping blood. Unless a device called a defibrillator is quickly used to correct the heart's rhythm, brain damage and death can happen.
  • Sudden cardiac death. This is the swift and not expected ending of all heart activity. Long QT syndrome has been linked to sudden cardiac death in young people who otherwise appear healthy. LQTS might be responsible for some unexplained events in children and young adults, such as unexplained fainting, drownings or seizures.

Proper medical treatment and lifestyle changes can help prevent complications of long QT syndrome.


There is no known way to prevent congenital long QT syndrome (LQTS). If someone in your family has LQTS, ask a health professional if genetic screening is right for you. With proper treatment, you can manage and prevent the dangerous heartbeats that can lead to LQTS complications.

Regular health checkups and good communication with your healthcare professional also may help prevent causes of some types of acquired long QT syndrome. It's especially important not to take medicines that can affect the heart rhythm and cause a prolonged QT interval.


To diagnose long QT syndrome (LQTS), a healthcare professional examines you. You are usually asked questions about your symptoms and medical and family history. The health professional listens to your heart with a device called a stethoscope that's placed against your chest. If your healthcare professional thinks you have an irregular heartbeat, tests can be done to check the heart.


Tests are done to check the health of the heart and confirm long QT syndrome (LQTS).

Electrocardiogram (ECG or EKG)

An ECG is the most common test used to diagnose long QT syndrome. It records the electrical signals in the heart and shows how fast or how slow the heart is beating. Sticky patches called electrodes attach to the chest and sometimes the arms and legs. Wires connect the electrodes to a computer, which prints or displays the test results. The heart's signals are shown as waves on the test results.

  • On an ECG, there are five waves. They use the letters P, Q, R, S and T.
  • Waves Q through T show the heart signaling in the heart's lower chambers.
  • The time between the start of the Q wave and the end of the T wave is called the QT interval. This is how long it takes for the heart to squeeze and refill with blood before it beats again. If the interval takes longer than usual to happen, it's called a prolonged QT interval.

An ideal QT interval depends on your age, your sex and your personal heart rate. In people who have a LQTS complication called torsades de pointes, the waves on the ECG results look twisted.

If long QT symptoms don't happen often, they may not be seen on a regular ECG. If so, your healthcare professional may ask you to wear a heart monitor at home. There are several different types.

  • Holter monitor. This small, portable ECG device records the heart's activity. It's worn for a day or two while you do your regular activities.
  • Event recorder. This device is like a Holter monitor, but it records only at certain times for a few minutes at a time. It's typically worn for about 30 days. You usually push a button when you feel symptoms. Some devices automatically record when an irregular heart rhythm is detected.

Some personal devices, such as smartwatches, have sensors that can take an ECG. Ask your healthcare professional if this is an option for you.

Exercise stress tests

These tests often involve walking on a treadmill or pedaling a stationary bike. A member of your care team checks your heart activity as you exercise. Exercise stress tests show how the heart reacts to physical activity. If you can't exercise, you may get medicine that increases the heart rate like exercise does. Sometimes an echocardiogram is done during a stress test.

Genetic testing

A genetic test is available to confirm long QT syndrome (LQTS). The test checks for gene changes that can cause the disorder. Check with your insurer to see if it is covered.

If you have long QT syndrome, your healthcare team may suggest that other family members also get genetic testing to check for the disorder.

Genetic tests for long QT syndrome can't find all inherited cases of long QT syndrome. It's recommended that families speak to a genetic counselor before and after testing.

Graphs of typical and prolonged QT intervals


Treatment for long QT syndrome (LQTS) may include:

  • Lifestyle changes.
  • Medicines.
  • A medical device.
  • Surgery.

The goals of LQTS treatment are to:

  • Prevent irregular heartbeats.
  • Prevent sudden cardiac death.

Your healthcare professional talks with you about your treatment options. Treatment depends on your symptoms and your type of long QT syndrome. You may need treatment even if you don't often have symptoms.


Some people with acquired long QT syndrome may get fluids or minerals, such as magnesium, through a needle in a vein.


If medicine causes long QT syndrome (LQTS), stopping the medicine may be all that's needed to treat the disorder. Your healthcare professional can tell you how to safely do so. Do not change or stop taking any medicines without talking to your healthcare team.

Some people with LQTS need medicines to treat symptoms and prevent life-threatening heart rhythm changes.

Medicines used to treat long QT syndrome may include:

  • Beta blockers. These medicines slow the heart rate. They reduce the chances of having a long QT episode. Beta blockers used to treat long QT syndrome include nadolol (Corgard) and propranolol (Inderal LA, InnoPran XL).
  • Mexiletine. Taking this heart rhythm medicine with a beta blocker might help shorten the QT interval. It can help lower the risk of fainting, seizure or sudden cardiac death.

Surgery or other procedures

Some people with long QT syndrome need surgery or a device to control the heartbeat. Surgery or other procedures used for LQTS treatment may include:

  • Left cardiac sympathetic denervation (LCSD) surgery. This surgery may be done if you have long QT syndrome and continuing heart rhythm changes but beta blockers don't work for you. It doesn't cure long QT syndrome. Instead, the surgery helps lower the risk of sudden cardiac death. In this treatment, surgeons remove specific nerves along the left side of the spine. These nerves are part of the body's sympathetic nervous system, which helps control the heart rhythm.
  • Implantable cardioverter-defibrillator (ICD). This device is placed under the skin near the collarbone. It continuously checks the heart rhythm. If the device finds an irregular heartbeat, it sends out low- or high-energy shocks to reset the heart's rhythm.

    Most people with long QT syndrome don't need an ICD. But the device may be suggested for some athletes to help them return to competitive sports. The decision to place an ICD, especially in children, needs to be carefully considered. Placing an ICD requires surgery. Sometimes the device may send out shocks that aren't needed. Talk with your healthcare team about the benefits and risks of an ICD.

Lifestyle and home remedies

Your healthcare professional may suggest lifestyle changes to help you manage long QT syndrome (LQTS). These changes can lower the risk of a fainting spell or sudden cardiac death linked with LQTS.

  • Know which sports are safe. You may be able to stay fully active in sports, including competitive sports. But talk to your healthcare team first. In general, people with long QT syndrome should never swim alone. Physical activities are likely to be okay if you take someone along who can help if you faint.
  • Check for startling sounds. Turn down the volume on doorbells and other devices such as phones that may startle you, especially during sleep. Things that startle you can cause you to pass out.
  • Control emotions. Being very excited, angry or surprised can trigger heartbeat changes in some people with long QT syndrome. Getting more exercise, practicing mindfulness and connecting with others in support groups are some ways to reduce stress.
  • Check your medicines. Don't take medicines that could cause prolonged QT intervals. If you're not sure whether you take such medicines, ask your healthcare professional. It's a good idea to let your healthcare team know about all the medicines and supplements you take, even those you buy without a prescription.
  • Get regular health checkups. If you have changes in your symptoms or overall health, your care team may update your treatment plan or suggest more treatments.

Coping and support

Worrying about possible dangerous heart rhythms linked with long QT syndrome (LQTS) may cause stress for you and your loved ones. Here are some things that might help you manage your condition.

  • Tell other people you have LQTS. Make family, friends, teachers, neighbors, and anyone else who has regular contact with you aware of your heart rhythm disorder and your symptoms. Wear a medical alert identification to show others that you have LQTS.
  • Have an emergency plan. Family members may want to learn cardiopulmonary resuscitation (CPR) so they can help if you ever need it. It may be appropriate to have or be able to rapidly get an automated external defibrillator (AED).
  • Seek support or counseling. It might be helpful to join a support group, where you can share your experiences and feelings with others who are familiar with long QT syndrome. Families with inherited long QT syndrome also might find it helpful to talk to a genetic counselor.

Preparing for an appointment

If you have pounding, fast or irregular heartbeats, make an appointment for a health checkup. You may be sent to a doctor trained in heart conditions. This type of healthcare professional is called a cardiologist.

You also might see a doctor trained in heart rhythm disorders, called an electrophysiologist.

Here's some information to help you prepare for your appointment and know what to expect from your healthcare team.

What you can do

  • Write down any symptoms you've had, and for how long. Include those that may not seem related to long QT syndrome.
  • Write down important medical information, including any other health conditions you have and the names and doses of any medicines that you take. It's also important to share any family history of irregular heartbeats or sudden death with your healthcare professional.
  • Write down the questions you want to be sure to ask your healthcare professional.

Questions to ask the healthcare professional at your first appointment include:

  • What is likely causing my symptoms?
  • Are there any other possible causes for these symptoms?
  • What tests do I need?
  • Should I see a specialist?

Questions to ask if you're sent to a cardiologist or electrophysiologist include:

  • Do I have long QT syndrome? If so, which type?
  • What is my risk of complications?
  • What treatment do you recommend?
  • If you're recommending medicines, what are the possible side effects?

Questions to ask if your healthcare professional recommends surgery include:

  • How will this type of surgery help me?
  • Where should I have my surgery done?
  • What should I expect from my recovery and rehabilitation after surgery?

Other questions include:

  • Do I need frequent health checkups and long-term treatment?
  • What emergency symptoms of long QT syndrome should I be aware of?
  • What activity restrictions do I need to follow?
  • What type of lifestyle changes do you recommend?
  • What medicines should I avoid taking?
  • What is my long-term outlook with treatment?
  • Is it safe for me to become pregnant in the future?
  • What is the risk that my future children will have long QT syndrome?
  • How can genetic counseling help my family?

Don't hesitate to ask other questions.

What to expect from your doctor

Your healthcare team may ask:

  • What are your symptoms?
  • When did the symptoms start?
  • Have the symptoms gotten worse over time?
  • Do strong emotions, such as anger, excitement or surprise, trigger your symptoms?
  • Does exercise cause symptoms?
  • Does being startled — such as by a doorbell or phone ringing — trigger your symptoms?
  • Do you ever feel dizzy or lightheaded?
  • Have you ever fainted?
  • Have you ever had a seizure?
  • What other medical conditions do you have?
  • Does anyone in your family have a heart condition or heart rhythm disorder?
  • Has a parent, brother, sister or child ever died by drowning or an unexpected cause?
  • What medicines are you currently taking?
  • Have you ever used illegal drugs? If so, which ones?
  • Do you use caffeine? How much?

Knowing as much as possible about your health and your family's health history helps your healthcare team learn your diagnosis and plan treatment.

What you can do in the meantime

While you wait for your appointment, ask your family members if anyone you're related to has a family history of long QT syndrome or unexplained death.

Content From Mayo Clinic Updated: 07/18/2024
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